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Tor eckhoff cause of death5/11/2023 ![]() cholerae colonization and not the diarrheagenic actions of cholera toxin, these strains were rendered nontoxigenic. Since the primary mechanism of immune protection against cholera is thought to be antibody responses that limit V. cholerae challenge strains (ZChol strains) derived from a contemporary Zambian clinical isolate representative of current dominant pandemic V. Here, we created next-generation isogenic Ogawa and Inaba O1 V. ![]() Human challenge studies are instrumental for testing cholera vaccines, but these studies use outdated strains and require inpatient facilities. ![]()
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